Jean L Chan Selected Research

recombinant methionyl human leptin

2/2009	r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: observational and interventional studies in humans.
7/2008	Leptin does not mediate short-term fasting-induced changes in growth hormone pulsatility but increases IGF-I in leptin deficiency states.
5/2008	Leptin does not directly regulate the pancreatic hormones amylin and pancreatic polypeptide: interventional studies in humans.
1/2008	Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: regulation by gender and adiposity.
7/2006	Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy.
5/2006	Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans.
3/2005	Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess.
5/2003	The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men.

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Jean L Chan Research Topics

Disease

10	Obesity 01/2016 - 03/2002
9	Insulin Resistance 11/2011 - 04/2003
7	Fibrosis (Cirrhosis) 01/2021 - 01/2019
7	Inflammation (Inflammations) 01/2021 - 01/2019
5	Lipodystrophy 01/2016 - 07/2006
5	Starvation 07/2008 - 05/2003
4	Body Weight (Weight, Body) 10/2009 - 09/2004
4	Amenorrhea 07/2008 - 03/2002
3	Alcoholic Fatty Liver 01/2021 - 01/2019
3	Portal Hypertension 01/2021 - 01/2019
3	Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy) 01/2016 - 03/2010
3	Weight Loss (Weight Reduction) 10/2009 - 02/2006
3	Type 2 Diabetes Mellitus (MODY) 05/2009 - 04/2003
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2009 - 09/2005
2	End Stage Liver Disease 01/2021 - 01/2019
2	Hepatitis C 01/2021 - 01/2019
2	Infections 03/2010 - 07/2006
2	Anorexia Nervosa 07/2005 - 07/2002
2	Feeding and Eating Disorders (Eating Disorder) 05/2003 - 03/2002
1	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 01/2022
1	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 01/2022
1	Hepatic Encephalopathy 01/2021
1	Hemorrhage 01/2021
1	Ascites 01/2021
1	Peritonitis 01/2021
1	Hepatorenal Syndrome 01/2021
1	Cicatrix (Scar) 01/2020
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020
1	Chronic Hepatitis (Chronic Active Hepatitis) 01/2019
1	Non-alcoholic Fatty Liver Disease 01/2019
1	Liver Diseases (Liver Disease) 01/2019
1	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2016
1	Lymphoma (Lymphomas) 01/2016
1	Metabolic Diseases (Metabolic Disease) 01/2016
1	Injection Site Reaction 01/2016
1	Burkitt Lymphoma (Burkitt's Lymphoma) 01/2016
1	Mycosis Fungoides 01/2016
1	Diabetes Mellitus 11/2011
1	Hypertriglyceridemia 11/2011
1	HIV Infections (HIV Infection) 02/2009
1	Hyperlipidemias (Hyperlipidemia) 07/2006
1	Osteoporosis 07/2005
1	Infertility (Sterility) 07/2005

Drug/Important Bio-Agent (IBA)

21	LeptinIBA 01/2016 - 03/2002
8	Hormones (Hormone)IBA 01/2022 - 10/2003
8	recombinant methionyl human leptinIBA 02/2009 - 05/2003
7	CaspasesIBA 01/2021 - 01/2019
7	3- (2- (2- tert- butylphenylaminooxalyl)aminopropionylamino)- 4- oxo- 5- (2,3,5,6- tetrafluorophenoxy)pentanoic acidIBA 01/2021 - 01/2019
6	Insulin (Novolin)FDA Link 02/2009 - 04/2003
5	metreleptinIBA 01/2016 - 10/2009
4	LipidsIBA 11/2011 - 10/2003
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2019
3	Triglycerides (Triacylglycerol)IBA 11/2011 - 09/2005
3	Glucose (Dextrose)FDA LinkGeneric 05/2008 - 09/2005
2	Pharmaceutical PreparationsIBA 01/2020 - 10/2009
2	pramlintide (Symlin)FDA Link 01/2016 - 10/2009
2	AdipokinesIBA 03/2010 - 06/2003
2	Islet Amyloid PolypeptideIBA 10/2009 - 05/2008
2	Biological ProductsIBA 10/2009 - 07/2002
2	Insulin-Like Growth Factor Binding ProteinsIBA 02/2009 - 07/2008
2	Insulin-Like Growth Factor I (IGF-1)IBA 07/2008 - 05/2003
2	Therapeutic UsesIBA 01/2008 - 03/2005
2	ResistinIBA 09/2005 - 10/2003
2	AdiponectinIBA 10/2003 - 06/2003
1	crinecerfontIBA 01/2022
1	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2022
1	AndrogensIBA 01/2022
1	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2021
1	SodiumIBA 01/2021
1	DiureticsIBA 01/2021
1	Alanine Transaminase (SGPT)IBA 01/2020
1	EnzymesIBA 01/2020
1	Transaminases (Aminotransferases)IBA 01/2019
1	BilirubinIBA 01/2019
1	Keratin-18 (Keratin 18)IBA 01/2019
1	Caspase 3 (Caspase-3)IBA 01/2019
1	AntibodiesIBA 01/2016
1	Neutralizing AntibodiesIBA 01/2016
1	Valsartan (Vals)FDA Link 05/2009
1	Angiotensin Receptor AntagonistsIBA 05/2009
1	Insulin-Like Growth Factor Binding Protein 6IBA 07/2008
1	Insulin-Like Growth Factor Binding Protein 3IBA 07/2008
1	Insulin-Like Growth Factor Binding Protein 4IBA 07/2008
1	Pancreatic HormonesIBA 05/2008
1	Pancreatic Polypeptide (Pancreatic Polypeptide (PP))IBA 05/2008
1	HDL LipoproteinsIBA 07/2006
1	CholesterolIBA 09/2005
1	Insulin-Like PeptidesIBA 07/2005
1	Interleukin-10 (Interleukin 10)IBA 03/2005
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 03/2005
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 03/2005
1	CytokinesIBA 03/2005

Therapy/Procedure

6	Therapeutics 01/2021 - 09/2004
3	Highly Active Antiretroviral Therapy (HAART) 02/2009 - 09/2005
2	Glycemic Control 03/2010 - 04/2003
2	Aftercare (After-Treatment) 03/2010 - 10/2009
1	Liver Transplantation 01/2021
1	Subcutaneous Injections 11/2011
1	Drug Therapy (Chemotherapy) 10/2009
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 02/2006